Prostaglandins in macula densa function
نویسندگان
چکیده
منابع مشابه
Macula densa cell signaling.
Macula densa cells are renal sensor elements that detect changes in distal tubular fluid composition and transmit signals to the glomerular vascular elements. This tubuloglomerular feedback mechanism plays an important role in regulating glomerular filtration rate and blood flow. Macula densa cells detect changes in luminal sodium chloride concentration through a complex series of ion transport...
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Annexin A1 (ANXA1) exerts anti-inflammatory effects through multiple mechanisms including inhibition of prostaglandin synthesis. Once secreted, ANXA1 can bind to G protein-coupled formyl peptide receptors (Fpr) and activate diverse cellular signaling pathways. ANXA1 is known to be expressed in cells of the juxtaglomerular apparatus, but its relation to the expression of cyclooxygenase 2 (COX-2)...
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In the juxtaglomerular apparatus of the kidney the distal tubule returns to its own glomerulus where specialised cells, the macula densa (MD) cells, are located so that they come in contact with the tubular fluid. It is well documented that MD cells sense the distal tubular flow-rate and that when the flow is too high they are activated, which leads to vasoconstriction of the afferent arteriola...
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To examine the role of the macula densa in renin release, afferent arterioles alone or afferent arterioles with the macula densa attached were microdissected from rabbit kidney and incubated in Medium 199 for two consecutive 30-minute periods. Renin concentration in the medium was measured using partially purified rabbit angiotensinogen. Renin release rate over 1 hour from a single arteriole (o...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1998
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.1998.06710.x